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Aristotle(384 BC - 322 BD),
Metaphysics


Lowering RBP4 could be a new strategy for treating type 2 diabetes
 One of the unexpected players in the nutrition and metabolism story is a small protein called RBP4. Until recently known only as a retinol (vitamin A) binding protein, its appearance in blood was surprisingly discovered to be a correlate of insulin resistance. Beyond a simple association a number of very elegant experiments have supported the idea.


Download full article:
RBP4 PDF

Recent Research

Metabolic consequences of incorrect insulin administration techniques in aging subjects with diabetes

 •Effects of a Mediterranean-Style Diet on the Need for Antihyperglycemic Drug Therapy in Patients With Newly Diagnosed Type 2 Diabetes A Randomized Trial
Katherine Esposito, MD, PhD; Maria Ida Maiorino, MD; Miryam Ciotola, MD; Carmen Di Palo, MD; Paola Scognamiglio, MD; Maurizio Gicchino, MD; Michela Petrizzo, MD; Franco Saccomanno, MD; Flora Beneduce, MD; Antonio Ceriello, MD; and Dario Giugliano, MD, PhD

Metabolic Syndrome and Changes in Body Fat From a Low-fat Diet and/or Exercise Randomized Controlled Trial
Sarah M. Camhi1, Marcia L. Stefanick, Peter T. Katzmarzyk and Deborah R. Young

Abdominal Adiposity Is Associated With Elevated C-Reactive Protein Independent of BMI in Healthy Nonobese People
Emanuela Lapice, MD, Simona Maione, BS, Lidia Patti, PHD, Paola Cipriano, BS, Angela A. Rivellese, MD, Gabriele Riccardi, MD and Olga Vaccaro, MD

Postprandial hyperglycemia as an etiological factor in vascular failure Koichi Node and Teruo Inoue Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan

Therapeutic role of low-carbohydrate ketogenic diet in diabetes
Alaa Al-Khalifa, M.Sc.a, Thazhumpal Chacko Mathew, M.Sc., Ph.D., F.R.C.Path.,a,b, Naji S. Al- Zaid, B.Sc., Ph.D.d, Elizabeth Mathew, B.Sc.a, and Hussein M. Dashti, M.D., Ph.D., F.I.C.S., F.A.C.S.

Effectiveness of Cinnamon for Lowering Hemoglobin A1C in Patients with Type 2 Diabetes: A Randomized, Controlled Trial
Paul Crawford, MD, J Am Board Family Med 2009;22:507–512.

Systematic Review: Glucose Control and Cardiovascular Disease in Type 2 Diabetes
Tanika N. Kelly, PhD; Lydia A. Bazzano, MD, PhD; Vivian A. Fonseca, MD; Tina K. Thethi, MD; Kristi Reynolds, PhD; and Jiang He, MD, PhD

Effects of a Mediterranean-Style Diet on the Need for Antihyperglycemic Drug Therapy in Patients With Newly Diagnosed Type 2 Diabetes

Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study
Tommy Jönsson, Yvonne Granfeldt, Bo Ahrén1, Ulla-Carin Branell, Gunvor Pålsson, Anita Hansson, Margareta Söderström and Staffan Lindeberg

Carbohydrate Restriction, as a First-Line Dietary Intervention, Effectively Reduces Biomarkers of Metabolic Syndrome in Emirati Adults
Taif Al-Sarraj, Hussein Saadi, Mariana C. Calle, Jeff S. Volek and Maria Luz Fernandez (abstract)

Glycemic control in newly diagnosed diabetes patients and mortality from ischaemic heart disease: 20-year follow-up of the HUNT Study in Norway abstract
Ane Cecilie Dale, Kristian Midthjell, Tom Ivar Nilsen, Rune Wiseth and Lars J. Vatten

Uncontrolled diabetes increases the risk of Alzheimer’s disease: a population-based cohort study
Diabetologia, June, 2009

Effect of oral acetyl L-carnitine arginate on resting and postprandial
blood biomarkers in pre-diabetics

Richard J Bloomer, Kelsey H Fisher-Wellman and Patrick S Tucker
Nutrition & Metabolism June 2, 2009

Carbohydrate Restriction has a More Favorable Impact
 on the Metabolic Syndrome than a Low Fat Diet

Jeff S. Volek, Stephen D. Phinney, Cassandra E. Forsythe, Erin E. Quann,
Richard J. Wood, Michael J. Puglisi, William J. Kraemer, Doug M. Bibus Maria Luz Fernandez, Richard D. Feinman

The effect of a low carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus
Eric C Westman, William S Yancy Jr., John C Mavropoulos, Megan Marquart and Jennifer R McDuffie Nutrition & Metabolism December 2008


PDF
Dietary Carbohydrate Restriction in the Treatment of Diabetes and Metabolic Syndrome
Richard D. Feinman, PhD, Jeff S. Volek, PhD, RD, and
Eric C. Westman, MD, MHS

PDFBenefit of Nuts in Type 2 Diabetes

Low-carbohydrate diet in type 2 diabetes: stable improvement ofbodyweight and glycemic control during 44 months follow-up
  Jörgen V Nielsen and Eva A Joensson

PDFDepression & Diabetes, JAMA June 18 2008

Effects of Intensive Glucose Lowering in Type 2 Diabetes The Action to Control Cardiovascular Risk in Diabetes Study Group NEJM June 2008

Arguments in favor of ketogenic diets
The Internet Journal of Nutrition & Wellness

Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal
Nutrition & Metabolism 2008, 5:9doi:10.1186/1743-7075-5-9

Has carbohydrate-restriction been forgotten as a treatment for diabetes mellitus? A perspective on the ACCORD study design. E Westman, MD, M Vernon, MD

Low carbohydrate diets improve atherogenic dyslipidemia even in the absence of weight loss. Richard D Feinman and Jeff S Volek

Short-term effects of severe dietary carbohydrate-restriction advice in type 2 diabetes - a randomized controlled trial. Daly ME, Paisey R, Paisey R, et al.: Diabet Med 2006; 23: 15-20.

Dietary treatment of diabetes mellitus in the pre-insulin.
Westman EC, Yancy Jr. WS, Humphreys M: era (1914-1922). Perspectives in Biology and Medicine 2006; 49: 77-83.

Low-carbohydrate diet in type 2 diabetes. Stable improvement of bodyweight and glycemic control during 22 months follow-up.
Jørgen Vesti Nielsen and Eva Jolensson

Control of blood glucose in type 2 diabetes without weight loss by modification of diet composition. Mary C Gannon and Frank Q Nuttall

A low-carbohydrate diet may prevent end-stage renal failure in type 2 diabetes.
A case report Jørgen Vesti Nielsen, Per Westerlund and Per Bygren

Mechanisms for Racial and Ethnic Disparities in Glycemic Control in Middle-aged and Older Americans in the Health and Retirement Study Mechanisms for racial/ethnic disparities in glycemic control are poorly understood.
Arch Intern Med. 2007;167:1853-1860.

2005

Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes.
Boden G, Sargrad K, Homko C, Mozzoli M, Stein TP: Ann Intern Med 2005; 142(6): 403-11.

Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction.
Jeff S Volek and Richard D Feinman

Comparison of High-Fat and High-Protein Diets with a High-Carbohydrate diet in Insulin-Resistant Obese Wo
men.

McAuley, K.A., Hopkins, C.M., Smith, K.J., et. alDiabetologia, 48(1), 2005, pages 8-16.

The case for low carbohydrate diets in diabetes management.
Surender K Arora and Samy I McFarlane

Dietary recommendations for people with diabetes: Time to reduce the carbohydrate loads.
Endocrine Today. 2005;3:4–5.

McFarlane SI. Dietary recommendations for people with diabetes: Time to reduce the carbohydrate loads.
Endocrine Today. 2005;3:4–5.

A low-carbohydrate, ketogenic diet to treat type 2 diabetes.
William S Yancy Jr ,Marjorie Foy, Allison M Chalecki , Mary C Vernon and Eric C Westman

2004

Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes.
Gannon MC, Nuttall FQ. Diabetes 2004;53(9):2375-82.

Improved plasma glucose control, whole-body glucose utilization, and lipid profile on a low-glycemic index diet in type 2 diabetic men: a randomized controlled trial.
Rizkalla SW, Taghrid L, Laromiguiere M, et al.: Diabetes Care 2004; 27(8):1866-72.

Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment.
2004: Gross LS, Li L, Ford ES, Liu S: Am J Clin Nutr 2004, 79:774-779.

2003

Importance of weight management in type 2 diabetes: review with meta-analysis of clinical studies.
Anderson JW, Kendall CWC, Jenkins DJA. J Am Coll Nutr 2003;22(5):331-9.

Low-glycemic index diets in the management of diabetes: a meta-analysis of randomized controlled trials.
Brand-Miller J, Hayne S, Petocz P, Colagiuri S. Diabetes Care 2003;26(8):2261-7.

An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes.
Gannon MC, Nuttall FQ, Saeed A, Jordan K, Hoover H: Am J Clin Nutr 2003; 78(4): 734-41.

glycemic control and serum lipids in diabetes mellitus.
O'Neill DF, Westman EC, Bernstein RK: Metabolic Syndrome and Related Disorders 2003; 1: 291-298.

Clinical experience of a carbohydrate-restricted diet: effect on diabetes mellitus.
Vernon MC, Mavropoulos J, Transue M, Yancy Jr WS, Westman EC: Metabolic Syndrome and Related Disorders 2003; 1(3): 233-237.

A pilot trial of a low-carbohydrate, ketogenic diet in patients with type 2 diabetes.
Yancy Jr WS, Vernon MC, Westman EC: Metabolic Syndrome and Related Disorders 2003; 1(3): 239-243.

The 1st World Congress on the Insulin Resistance Syndrome
ZACHARY T. BLOOMGARDEN, MD

2002

The effect of a high- and low-glycemic index energy restricted diets on plasma lipid and glucose profiles in type 2 diabetic subjects with varying glycemic control.
Heilbronn LK, Noakes M, Clifton PM: J Am Coll Nutr 2002; 21: 120-127.

Reduction in the incidence of type 2 diabetes with lifestyle change or metformin

The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease.
Ludwig DS: JAMA 2002; 287(18): 2414-23.

Glycemic index, glycemic load, and risk of type 2 diabetes.
Willett W, Manson J, Liu S: Am J Clin Nutr 2002; 76(1): 274S-80S.

1999

Effect of energy restriction, weight loss, and diet composition on plasma lipids and glucose in patients with type 2 diabetes.
Heilbronn LK, Noakes M, Clifton PM: Diabetes Care1999; 22(6): 889-95.

1998

Utility of a short-term 25% carbohydrate diet on improving glycemic control in type 2 diabetes mellitus.
Gutierrez M, Akhavan M, Jovanovic L, Peterson CMJ Am Coll Nutr 1998; 17(6): 595-600.

1994

Comparison of varying carbohydrate content of diet in patients with non-insulin-dependent diabetes mellitus.
Garg A, Bantle JP, Henry RR, et al. JAMA;271:1421-8.

1989

Comparison of hypertriglyceridemic effect of low-fat high-carbohydrate diets in NIDDM patients.
Coulston AM, Hollenbeck CB, Swislocki AL, Reaven GM. Diabetes Care 1989;12:94-101.

1988

Comparison of a high-carbohydrate diet with a high-monounsaturated-fat diet in patients with non-insulin-dependent diabetes mellitus.
Garg A, Bonanome A, Grundy SM, Zhang ZJ, Unger RH. N Engl J Med 1988;319:829-34.

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